Pekaline®

Patented depigmenting active ingredient

With Doctor Robert Ballotti and Professor Jean-Paul Ortonne, both hospital dermatologists and researchers at a large French institute, CEBELIA, an expert in patented treatments for aesthetic medicine, participated in very innovative work to patent a new regulator of melanogenesis and fight against skin hyperpigmentation.

Normal skin pigmentation is mainly due to melanin. Melanocytes are the cells of the epidermis responsible for the synthesis of melanin through the phenomenon of melanogenesis, and provide a protective role against UV rays. Under the effect of UV rays, in skin in good working order, hormones and enzymes (&MSH, PKA, tyrosinase, etc.) stimulate the production of melanin. This production of pigments is retained in bags, the melanosomes, then sent to the upper layers of the epidermis.

This is the tanning phenomenon which is normally uniform. Skin hyperpigmentation can be due either to the abnormal presence in the skin of a pigment of endogenous or exogenous origin (medications, etc.) or to an accumulation or a distribution disorder of melanin (exposure to the sun, hormonal disorders, etc.). ).

Discover our solution, a patented depigmenting active ingredient that reduces the level of melanin within your cells. Its name: Pekaline.

In order to act on the overall process of melanogenesis, we have selected a patented active ingredient, Pekaline, which acts on two levels:

A protein kinase A (PKA) inhibitor, it blocks transcription of the tyrosinase gene and therefore melanin synthesis.
It modifies the intramelanosomal pH which plays a crucial role in the control of melanogenesis. The pH inside the melanosomes becomes acidic (pH < 7) which inhibits melanogenesis.

Thus, it causes a blockage of melanin synthesis inside cells by inhibition of protein kinase (PKA) and pigment maturation (acidic pH).

The results are proven: Pekaline reduces the level of melanin in cells by 40% on so-called “healthy” cells and goes so far as to divide this level by 5 when they are activated by a stimulator of the tyrosinase enzyme. Pekaline also reduces existing pigmentation by approximately 50%.

This patented active ingredient is at the heart of the formulation of our Reinforced Depigmentant, a formula which combines Vitamin C, Vitamin PP and Glycolic Acid for their anti-dark spots synergy. It also makes up our Eye Brightener treating hyperpigmentation around the eyes causing dark circles.

Our face creams use Pekaline to fight against pigment spots, whether they are already present or forming. Thus, our depigmenting face creams allow you to see the first results after 2 months, as part of daily use of this solution.

Depigmenting treatment: What is it for?

A depigmenting treatment for facial skin is designed to help reduce the appearance of age spots and even out skin tone. These age spots can be caused by excessive sun exposure, aging, hormonal imbalances or other factors. The role of a depigmenting treatment is to reduce excess melanin, which is the pigment responsible for skin color, in areas where it is present in excess. Active ingredients used in these treatments may include lightening agents such as glycolic acid, salicylic acid or Pekaline. These ingredients work by blocking or inhibiting the production of melanin, which can help reduce the appearance of age spots and even out skin tone. Thus, depigmenting treatments can be used to treat pigmentation problems such as brown spots, age spots, sun spots and melasma.

At Cebelia, we are experts in dermo-aesthetic care. Also discover our patented active ingredient which promotes skin healing: Cebeline.

Why choose Pekaline as an intensive depigmenting treatment?

French dermo-aesthetic care brand that focuses on the research and development of innovative formulas to treat skin problems, Cebelia is supported by a team of researchers, dermatologists and pharmacists, who work together to develop high-quality products. quality and efficient. We are therefore renowned for being at the forefront of skin care technology. Our work on Pekaline led us to design an intensive depigmenting treatment that is suitable for all skin types, including the most sensitive. Thus, our depigmenting treatment enriched with Pekaline can be used by anyone wishing to reduce the pigmentation of their skin or prevent the appearance of brown spots.

How to include an anti-melanin depigmenting treatment in your routine?

To have blemish-free skin and an even complexion, you can include an anti-melanin depigmenting treatment in your beauty routine. You will find Pekaline (our patented active ingredient) in several of our products. To start, make sure to cleanse your skin regularly to rid it of impurities accumulated throughout the day. Then, apply our reinforced depigmentant and massage in circular movements to fully penetrate the product. Let your skin rest for a moment, then finish your beauty routine using our customizable serum. So, depending on the needs of your skin, you can decide which concentrates you need among hydration, anti-aging, radiance or depigmentation of spots on your skin. In addition to your treatment, it is important to choose products appropriate to your skin type and to use adequate sun protection to prevent the formation of new pigment spots. Our teams are at your disposal for any additional information on our products.
 

In addition to our reinforced depigmenting cream, discover our anti-stain hand cream
Always formulated with our patented active ingredient, Pekaline, our anti-stain depigmenting cream for hands acts on stains currently forming. It intensely nourishes and hydrates your skin. It also erases excess melanin that appears with age. In addition to Pekaline, our product is composed of natural sweet almond oil to protect your epidermis, but also of allantoin and glycerin, for deep hydration of your skin.

CEBELIA is committed to offering you products of exceptional quality. We guarantee the effectiveness of our creams with depigmenting active ingredients. These are clinically tested to offer you rapid and effective results, thanks to the expertise of our doctors and surgeons.