Cebeline®

Actif réparateur de la Jonction Dermo-Épidermique

We worked with Dr. Patricia Rousselle, a world-renowned specialist in the field of Laminins (LNs). For around twenty years, she has focused her research on the mechanisms involved in maintaining the cohesion of the epithelial basal laminae, choosing to use the model of the epidermis of human skin.

With her and her teams, we became interested in skin healing and more specifically in the role played by the LN-5 protein in it. Indeed, at the heart of the dermo-epidermal junction, there are anchoring fibers, which allow it to resist stress. Among these fibers, Laminin 5 (LN-5) is the major and irreplaceable adhesion protein of the epidermis. LN-5 plays a structural role and helps maintain skin cohesion. In addition, it carries biological signals, determining for the adhesion of keratinocytes.

The aim of the study was to isolate the active fragment of LN-5. The methodology consists of synthesizing peptide fragments of particular interest with regard to adhesion properties. Thus, several peptides were prepared by choosing the sequences in different areas in order to identify the most active ones. They thus identified the Cebeline peptide, a sequence present on the gamma 2 arm of LN-5, which specifically induces the adhesion of epidermal keratinocytes and other epithelial cells, in a dose-dependent manner.

The Cebeline peptide has several characteristics which allow it to cross the epidermis, reach the dermo-epidermal junction, interact with basal keratinocytes and transmit adhesion induction signals: a low molecular weight, a small size and good stability.

In addition, this peptide increases the adhesion of cells to the extracellular matrix but also the adhesion of cells to each other. A fragment of LN-5, the Cebeline peptide restores its native or deficient counterpart. It has an immediate biological activity of inducing adhesion and restoring the properties of the dermo-epidermal junction. It thus restarts the restructuring and repair of the skin.

This patented active ingredient is at the origin of the formulation of the L.C.E. Balm, and given the success and results obtained among practitioners, we have developed this restorative and anti-aging range with the Intensive Anti-Aging, the L.C.E. Look and also Extreme Care.