The dermal-epidermal junction is the area of tissue that joins the dermal and the epidermal layers of the skin. Also known as the epidermal basement membrane zone, it is divided into four parts:
The dermal-epidermal junction has several essential functions:
With time (oxidization, hormone changes, etc.), or due to external environmental factors, the skin becomes thinner: the dermis and epidermis weaken and the regeneration rate of keratinocytes slows down. The properties of the DEJ are altered: interaction between the dermis and the epidermis is reduced, adhesion of keratinocytes decreases and the area of contact becomes flatter. When the skin’s repair process slows down, wrinkles form and the skin starts to sag.
CEBELIA’s anti-ageing approach zeroes in on the dermal-epidermal junction and more particularly on the role of laminins and anchoring filaments. Thanks to the collaboration with Dr. Patricia Rousselle and her teams, CEBELINE, an active fragment of Laminin 5, has been developed to maintain the go od integrity of the DEJ
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