Kligman’s trio is a magistral preparation using hydroquinone, that is prescribed by a dermatologist and prepared by a pharmacist. This skincare product is one of the most effective at fighting spots on the skin and hands. Because Kligman’s trio is unstable and oxidizes quickly when exposed to light, the preparation should be refrigerated and replaced monthly. Medical follow-up is imperative throughout use of the product.


The depigmenting effects can be seen beginning in the second week. A maintenance product is necessary because the effect is only temporary.

Possible side effects

The side effects of hydroquinone may include irritation or contact allergy. White spots have even been described after prolonged usage at strong concentrations in patients with high phototypes.

Number of sessions & budget

Around €30 per tube

  • 30ml bottle

    CEBELIA Reinforced Depigmenting is an intense spot-reducing skincare for the face and hands. Designed and developed with aesthetic doctors, this anti-brown spot cream contains a unique combination of depigmenting agents that reduce brown spots and brighten dull complexions. Pekaline, a patented active ingredient and the fruit of a partnership with a...

    48,50 €
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  • 40ml tube

    CEBELIA Comfort Cream is a face and neck skincare, protecting the skin from the environmental stress it faces daily: extreme climatic conditions (humidity, dryness), temperature changes, urban pollution, cigarettes smoke, air conditioning... Thanks to the association of a biotechnological moss and active ingredients essential to skin balance, our Comfort...

    27,80 €
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  • 75ml tube

    CEBELIA Extreme Care is a complete soothing and moisturizing skincare for the face and body. Designed to soothe the skin after aesthetic procedures like peeling treatments, it is an SOS emergency skincare that cools the epidermis and immediately calms reactive and damaged skin. Its active ingredients reduce redness, lower the skin's temperature, rehydrate...

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  • 30ml bottle

    CEBELIA Intensive Anti-Aging facial skincare is a complete anti-wrinkle, firming skincare that recovers the radiance and suppleness of the skin on the face and chest. Its patented active agent, Cebeline, acts on cellular regeneration by restoring the dermal-epidermal junction, thereby fighting the ageing of the skin. The patent was developed in...

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  • 14,65 € We are currently out of stock. Available from November 2018.

    75ml tube

    CEBELIA Multi-Active Cream is a repairing cream for dry hands and damaged nails. This nourishing, protective skincare rehydrates the skin and strengthens the nails. Its smooth texture provides immediate relief to dry hands and soothes irritation. Its active ingredients return the skin's suppleness and softness and strengthen damaged nails.

    14,65 €
    We are currently out of stock. Available from November 2018.

PROLONG: to prolong the effects of Kligman’s trio, use CEBELIA Reinforced Depigmenting to lighten the complexion and cause spots to fade. Apply once or twice daily to freshly cleansed skin.

Next, depending on your skin type, apply:
CEBELIA Intensive Anti-Aging to fight the signs of age with a firming, lifting effect. Apply morning and/or night to the freshly cleansed face, neck and chest.
CEBELIA Extreme Care to soothe and intensely hydrate sensitive skin. Suitable for normal, combination and oily skin, thanks to its light gel/cream texture. Apply as often as necessary.
CEBELIA Comfort Cream to nourish and protect dry skin. Apply morning and/or night to the freshly cleansed face, neck and chest.
CEBELIA Multi-Active Cream for hands and nails to nourish and protect the hands. Apply as often as necessary, massaging in until the product has been completely absorbed.


Efficacy on the mask of pregnancy and brightening the complexion when used in combination with a medical protocol.

Use of a Kligman's trio depigmenting treatment for one month, followed by a fruit acid peel and finally one month of application of CEBELIA Reinforced Depigmenting (twice daily with SPF 50 sunscreen).

Results :significant brown spot reduction. The complexion is brighten and more radiant

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